Dear Dr. Blake Przewoski,
I hope this email finds you well and you are enjoying your new position at NextGEN Institute.
I've been reviewing your recent paper on CRISPR-Cas13d system modifications. The results with the phosphorothioate-modified guide RNAs are particularly intriguing.
Have you considered testing the system with TNA modifications? Our lab has seen promising results with TNA in terms of nuclease resistance.
Best regards,
Xiao